In order to achieve maximum genetic potential in poultry meat production or egg production it is necessary to maintain a high level of bird health through vaccination against viral and bacterial challenges; and limiting food and water borne microbial contamination. Many factors can influence the final efficacy of this through immunosuppression, which can be caused by low levels of mycotoxins, resulting in reduced protection against specific challenges as Infectious Bronchitis, Coccidia and E. coli. Bacterial challenges such as Necrotic Enteritis are opportunistic and cause serious economic loss, particularly in broilers or turkeys, often following intestinal challenges such as coccidiosis. Therefore improving vaccine efficacy along with reducing the possibilities for colonisation in the intestine by pathogenic organisms as Salmonella, Campylobacter, Clostridium or E coli will significantly improve performance in both breeder and commercial stock. Whether it is through mycotoxin risk management to improve vaccine protection, or reducing the levels of microbial challenge or colonisation BIOMIN technical managers can advise on the most effective products to achieve the required outcome of improved performances.