Bacteria are part of one’s life. They are everywhere around us as well as in our gastrointestinal tract or in other parts of hollow organs. As long as there is a balance between growth and death of bacteria every process remains normal in the organism. But what happens when this balance is disturbed? What happens when more bacteria than those the organism can cope with are produced? In this case bacteria have the chance to liberate their poisonous substances or compete against the body’s defenses consequently harming it. What about information regarding endotoxins, the structural components of bacteria which are not produced but rather released by them upon bacterial multiplication, lyses and/or death?
Classically, an endotoxin (commonly referred on literature as lipopolysaccharides, LPS) is a toxin that, unlike an exotoxin, is not secreted in soluble form by live bacteria, but instead represents a structural component present in the cell wall of Gram-negative bacteria (e.g. E.coli, Salmonella, Shigella, Pseudomonas, amongst others) independently of the fact if the organisms are pathogenic or not.
There are many natural sources of endotoxins and they can be classified as exogenous (namely air, food, water, feces and urine) and endogenous (colonized mucosa, gastrointestinal tract, wounds, traumas, abscesses, bacteria in blood and lymph and fat tissue mobilization).