“This marks a major step in achieving an additional EU authorization for FUMzyme®. For the poultry industry, it means a new, innovative tool for mycotoxin risk management proven to deactivate fumonisins safely and effectively,” stated Ursula Hofstetter, Director Competence Center Mycotoxins at BIOMIN.
EFSA acknowledged the efficacy of FUMzyme® in degrading fumonisins to non-toxic compounds in the gastrointestinal tract of poultry, as demonstrated in numerous feeding trials.
Recent BIOMIN Mycotoxin Survey results of 3065 samples taken in the first half of 2016 indicate that fumonisins were detected in 80% of maize, 27% of wheat, 66% of finished feed and 40% of soybean meal samples.
“We know that fumonisins impair the health and performance of poultry,” remarked Ms Hofstetter. Recent research revealed that the ingestion of fumonisins at levels below the EU recommended value (20 parts per million) can affect the expression of proteins related to pro- and anti-inflammatory responses in the intestinal tract of broilers.
Levels of 20 ppm of fumonisins induce a higher excretion of Eimeria, the parasites responsible for coccidiosis. “In large-scale farms, this may promote parasite transmission between birds due to the high density of the animals,” she explained.
Method of choice
Due to the molecular structure of fumonisins, adsorptive substances, or binders, are not suitable to fully counteract fumonisins. FUMzyme® the first-ever purified enzyme authorized by the EU to biotransform fumonisins specifically and irreversibly into non-toxic metabolites.
“Biotransformation is the most cutting-edge strategy to detoxify mycotoxins,” said Ms Hofstetter. Biotransformation works by transforming non-adsorbable mycotoxins into harmless substances without any side effects for livestock. “It’s the future of mycotoxin risk management,” she added.
Demonstrating the effectiveness of FUMzyme® involved evidence using the serum sphinganine/sphingosine ratio, a key biomarker that indicates fumonisin exposure in animals. Trials consistently demonstrated that the addition of FUMzyme® significantly reduced the sphinganine/sphingosine ratio in the blood of poultry fed fumonisin-contaminated diets down to levels similar to those in birds fed uncontaminated diets.
FUMzyme®, the result of years of intensive scientific research from the BIOMIN Research Center, achieved its initial EU authorization in 2014. It was originally isolated from the fumonisin degrading soil bacterium Sphingopyxis sp. MTA 144 and identified as fumonisin esterase by the BIOMIN Research Center. The purified-enzyme that specifically biotransforms fumonisins exemplifies the pioneering role of BIOMIN in developing advanced strategies to counteract mycotoxins.