The use of AGPs in the animal feed industry has been decreasing due to their link with antimicrobial resistance. Concerns around increasing levels of antimicrobial resistance has resulted in AGP bans in several countries. In 2006, the use of AGPs in animal feed was banned in the EU. In 2017, the Food and Drug Administration (FDA) brought in new rules sharply curtailing the routine use of antibiotics on farms across the US.
Since the restriction of AGPs, the animal feed industry has faced the big problem of finding adequate replacements in order to sustain and even increase output to meet the growing demand for animal protein worldwide. The main mode of action of AGPs is assumed to be their antiinflammatory properties (Niewold, 2007), hence alternative products with similar effects on the inflammatory system are highly sought after.